📰 最近消息
12/28Glassfrogs conceal blood in their liver to maintain transparency (Science 2022 Duke)glass frogs are able to maintain a high level of transparency because a large proportion of their red blood cells are “hidden” in the liverThis strategy allows the frogs to attain transparency when they are the
1/14ATP as a biological hydrotrope (Science 2017 MPI)Hydrotropes are small molecules that solubilize hydrophobic molecules in aqueous solutions.ATP at concentrations found in cells could act as a hydrotrope to help solubilize hydrophobic proteins.ATP inhibits the phase separation of unstructured pro
1/14Action at a distance during cytokinesis (JCB 2009 UW & UWM)cells depleted of astral microtubules conduct accurate, complete cytokinesisasters alone can support furrow induction without a spindle, but only when sufficiently separatedAblation of a single centrosome displaces furrows away from the
1/14A mitotic chromatin phase transition prevents perforation by microtubules (Nature 2022 Australia)a substantial global reduction in chromatin solubility caused by deacetylation during mitotic entry converts chromosomes into phase-separated bodies rather than loose bottlebrush structures with chro
1/14Prc1E and Kif4A control microtubule organization within and between large Xenopus egg asters (2018 MBoC Tim Mitchison)conserved cytokinesis midzone proteins: Prc1 and Kif4A. Prc1EPrc1E was required for Kif4A recruitment but not vice versaplus-end growth slowed and terminated preferentially withi
1/15In Vitro Reconstitution of Self-Organizing Protein Patterns on Supported Lipid Bilayers (2018 Jove)Escherichia coli MinCDE system (a reaction-diffusion system) - This system is based on the ATPase MinD, the ATPase activating protein MinE, and the membrane as a spatial reaction matrix; MinC is no
1/22A tug of war between filament treadmilling and myosin induced contractility generates actin rings (2022 elife)Actin filaments are highly dynamic, undergoing rapid polymerization and depolymerization, and are subject to contractile forces generated by myosin motorsActin polymerization is polarize
1/22ImportinImportin is a type of karyopherin that transports protein molecules from the cell's cytoplasm to the nucleus. It does so by binding to specific recognition sequences, called nuclear localization sequences (NLS).Importin has two subunits, importin α and importin β. Members of the importin
1/12Importin α partitioning to the plasma membrane regulates intracellular scalingThese experiments identify importin α as a conserved surface area-to-volume sensor that scales intracellular structures to cell size.
2/16Rapid evolution of protein diversity by de novo origination in Oryza (Nature Ecology & Evolution 2019 UChicago)